AustralieFrV1, Main, Exploration, bibRecord, 002D00

Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium

Identifieur interne : 002D00 ( Main/Exploration ); précédent : 002C99; suivant : 002D01

Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium

Auteurs : Helen D. Bailey [France] ; Claire Infante-Rivard [Canada] ; Catherine Metayer [États-Unis] ; Jacqueline Clavel [France] ; Tracy Lightfoot [Royaume-Uni] ; Peter Kaatsch [Allemagne] ; Eve Roman [Royaume-Uni] ; Corrado Magnani [Italie] ; Logan G. Spector [États-Unis] ; Eleni Petridou [Grèce] ; Elizabeth Milne [Australie] ; John D. Dockerty [Nouvelle-Zélande] ; Lucia Miligi [Italie] ; Bruce K. Armstrong [Australie] ; Jérémie Rudant [France] ; Lin Fritschi [Australie] ; Jill Simpson [Royaume-Uni] ; Luoping Zhang [États-Unis] ; Roberto Rondelli ; Margarita Baka [Grèce] ; Laurent Orsi [France] ; Maria Moschovi [Grèce] ; Alice Y. Kang [États-Unis] ; Joachim Schüz [France]

Source :

International journal of cancer. Journal international du cancer [ 0020-7136 ] ; 2015.

RBID : PMC:4572913

Descripteurs français

KwdFr :
- Effets différés de l'exposition prénatale aux facteurs de risque (épidémiologie), Enfant, Enfant d'âge préscolaire, Exposition environnementale (effets indésirables), Exposition maternelle (effets indésirables), Facteurs de risque, Femelle, Grossesse, Humains, Leucémie aigüe myéloïde (épidémiologie), Leucémie-lymphome lymphoblastique à précurseurs B et T (épidémiologie), Modèles logistiques, Mâle, Nourrisson, Nouveau-né, Odds ratio, Pesticides (toxicité), Risque, Études cas-témoins.
MESH :
- effets indésirables : Exposition environnementale, Exposition maternelle.
- toxicité : Pesticides.
- épidémiologie : Effets différés de l'exposition prénatale aux facteurs de risque, Leucémie aigüe myéloïde, Leucémie-lymphome lymphoblastique à précurseurs B et T.
- Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grossesse, Humains, Modèles logistiques, Mâle, Nourrisson, Nouveau-né, Odds ratio, Risque, Études cas-témoins.

English descriptors

KwdEn :
- Case-Control Studies, Child, Child, Preschool, Environmental Exposure (adverse effects), Female, Humans, Infant, Infant, Newborn, Leukemia, Myeloid, Acute (epidemiology), Logistic Models, Male, Maternal Exposure (adverse effects), Odds Ratio, Pesticides (toxicity), Precursor Cell Lymphoblastic Leukemia-Lymphoma (epidemiology), Pregnancy, Prenatal Exposure Delayed Effects (epidemiology), Risk, Risk Factors.
MESH :
- chemical , toxicity : Pesticides.
- adverse effects : Environmental Exposure, Maternal Exposure.
- epidemiology : Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prenatal Exposure Delayed Effects.
- Case-Control Studies, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Logistic Models, Male, Odds Ratio, Pregnancy, Risk, Risk Factors.

Abstract

Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control studies in the Childhood Leukemia International Consortium (CLIC). Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukaemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval (CI) 1.25, 1.55) (using (2,785 cases, 3635 controls), 1.43 (95% CI 1.32, 1.54) (5,055 cases, 7,370 controls) and 1.36 (95% CI 1.23, 1.51) (4,162 cases 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukaemia (AML) were 1.49 (95% CI 1.02, 2.16) (173 cases, 1,789 controls), 1.55 (95% CI 1.21, 1.99) (344 cases, 4,666 controls) and 1.08 (95% CI 0.76, 1.53) (198 cases, 2,655 controls) respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukaemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants’ exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate associations between home pesticide use and childhood leukaemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572913

DOI: 10.1002/ijc.29631
PubMed: 26061779
PubMed Central: 4572913

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium</title>
<author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name>
<affiliation wicri:level="3"><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name>
<affiliation wicri:level="3"><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Berkeley, School of Public Health, Berkeley</wicri:regionArea>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>RNHE - National Registry of Childhood cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of York, York</wicri:regionArea>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name>
<affiliation wicri:level="1"><nlm:aff id="A8">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz</wicri:regionArea>
<wicri:noRegion>Johannes Gutenberg University Mainz</wicri:noRegion>
<wicri:noRegion>Johannes Gutenberg University Mainz</wicri:noRegion>
<wicri:noRegion>Johannes Gutenberg University Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of York, York</wicri:regionArea>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara</wicri:regionArea>
<wicri:noRegion>Novara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Telethon Kids Institute, University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Telethon Kids Institute, University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin</wicri:regionArea>
<wicri:noRegion>Dunedin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name>
<affiliation wicri:level="1"><nlm:aff id="A15">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name>
<affiliation wicri:level="4"><nlm:aff id="A16">Sydney School of Public Health, University of Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney School of Public Health, University of Sydney, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Sax Institute, Ultimo, NSW, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Sax Institute, Ultimo, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>RNHE - National Registry of Childhood cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Curtin University, School of Public Health, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin University, School of Public Health, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of York, York</wicri:regionArea>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name>
<affiliation wicri:level="3"><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Berkeley, School of Public Health, Berkeley</wicri:regionArea>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name>
<affiliation><nlm:aff id="A19">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff>
<wicri:noCountry code="subfield">Policlinico Sant’Orsola Malpighi Bologna Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y" last="Kang">Alice Y. Kang</name>
<affiliation wicri:level="3"><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Berkeley, School of Public Health, Berkeley</wicri:regionArea>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
<affiliation wicri:level="3"><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26061779</idno>
<idno type="pmc">4572913</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572913</idno>
<idno type="RBID">PMC:4572913</idno>
<idno type="doi">10.1002/ijc.29631</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">001C56</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C56</idno>
<idno type="wicri:Area/Pmc/Curation">001B14</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B14</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000F42</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F42</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002691</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002691</idno>
<idno type="wicri:Area/PubMed/Curation">002622</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002622</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002622</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002622</idno>
<idno type="wicri:Area/Ncbi/Merge">002687</idno>
<idno type="wicri:Area/Ncbi/Curation">002687</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002687</idno>
<idno type="wicri:doubleKey">0020-7136:2015:Bailey H:home:pesticide:exposures</idno>
<idno type="wicri:Area/Main/Merge">002D00</idno>
<idno type="wicri:Area/Main/Curation">002D00</idno>
<idno type="wicri:Area/Main/Exploration">002D00</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium</title>
<author><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name>
<affiliation wicri:level="3"><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name>
<affiliation wicri:level="3"><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Berkeley, School of Public Health, Berkeley</wicri:regionArea>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>RNHE - National Registry of Childhood cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of York, York</wicri:regionArea>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name>
<affiliation wicri:level="1"><nlm:aff id="A8">German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz</wicri:regionArea>
<wicri:noRegion>Johannes Gutenberg University Mainz</wicri:noRegion>
<wicri:noRegion>Johannes Gutenberg University Mainz</wicri:noRegion>
<wicri:noRegion>Johannes Gutenberg University Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of York, York</wicri:regionArea>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Medicina Traslazionale – Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO – Piemonte, Novara</wicri:regionArea>
<wicri:noRegion>Novara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Medical School, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Telethon Kids Institute, University of Western Australia, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Telethon Kids Institute, University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Dean's Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin</wicri:regionArea>
<wicri:noRegion>Dunedin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name>
<affiliation wicri:level="1"><nlm:aff id="A15">ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name>
<affiliation wicri:level="4"><nlm:aff id="A16">Sydney School of Public Health, University of Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney School of Public Health, University of Sydney, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Sax Institute, Ultimo, NSW, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea>Sax Institute, Ultimo, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">RNHE - National Registry of Childhood cancers, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>RNHE - National Registry of Childhood cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Curtin University, School of Public Health, Perth, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Curtin University, School of Public Health, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Health Sciences, University of York, York, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of York, York</wicri:regionArea>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name>
<affiliation wicri:level="3"><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Berkeley, School of Public Health, Berkeley</wicri:regionArea>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name>
<affiliation><nlm:aff id="A19">Paediatric Haematology -Oncology, Lalla Seràgnoli, Policlinico Sant’Orsola Malpighi Bologna Italy</nlm:aff>
<wicri:noCountry code="subfield">Policlinico Sant’Orsola Malpighi Bologna Italy</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pediatric Hematology-Oncology, ‘‘Pan.&Agl. Kyriakou’’ Children’s Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A5">Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, ‘‘Aghia Sophia’’ General Children’s Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y" last="Kang">Alice Y. Kang</name>
<affiliation wicri:level="3"><nlm:aff id="A3">University of California, Berkeley, School of Public Health, Berkeley, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of California, Berkeley, School of Public Health, Berkeley</wicri:regionArea>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
<affiliation wicri:level="3"><nlm:aff id="A1">International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of cancer. Journal international du cancer</title>
<idno type="ISSN">0020-7136</idno>
<idno type="eISSN">1097-0215</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Environmental Exposure (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Leukemia, Myeloid, Acute (epidemiology)</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Maternal Exposure (adverse effects)</term>
<term>Odds Ratio</term>
<term>Pesticides (toxicity)</term>
<term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (epidemiology)</term>
<term>Pregnancy</term>
<term>Prenatal Exposure Delayed Effects (epidemiology)</term>
<term>Risk</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Effets différés de l'exposition prénatale aux facteurs de risque (épidémiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Exposition environnementale (effets indésirables)</term>
<term>Exposition maternelle (effets indésirables)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Leucémie aigüe myéloïde (épidémiologie)</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B et T (épidémiologie)</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Odds ratio</term>
<term>Pesticides (toxicité)</term>
<term>Risque</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Pesticides</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term>
<term>Maternal Exposure</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Exposition environnementale</term>
<term>Exposition maternelle</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Leukemia, Myeloid, Acute</term>
<term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term>
<term>Prenatal Exposure Delayed Effects</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Pesticides</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Effets différés de l'exposition prénatale aux facteurs de risque</term>
<term>Leucémie aigüe myéloïde</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B et T</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Odds Ratio</term>
<term>Pregnancy</term>
<term>Risk</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Odds ratio</term>
<term>Risque</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case-control studies in the Childhood Leukemia International Consortium (CLIC). Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukaemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval (CI) 1.25, 1.55) (using (2,785 cases, 3635 controls), 1.43 (95% CI 1.32, 1.54) (5,055 cases, 7,370 controls) and 1.36 (95% CI 1.23, 1.51) (4,162 cases 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukaemia (AML) were 1.49 (95% CI 1.02, 2.16) (173 cases, 1,789 controls), 1.55 (95% CI 1.21, 1.99) (344 cases, 4,666 controls) and 1.08 (95% CI 0.76, 1.53) (198 cases, 2,655 controls) respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukaemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants’ exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate associations between home pesticide use and childhood leukaemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Nouvelle-Zélande</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Attique (région)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Nouvelle-Galles du Sud</li>
<li>Québec</li>
<li>Rhône-Alpes</li>
<li>Île-de-France</li>
</region>
<settlement><li>Athènes</li>
<li>Berkeley (Californie)</li>
<li>Lyon</li>
<li>Montréal</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name>
</noCountry>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D" last="Bailey">Helen D. Bailey</name>
</region>
<name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
</country>
<country name="Canada"><region name="Québec"><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name>
</region>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name>
</region>
<name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y" last="Kang">Alice Y. Kang</name>
<name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name>
<name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G" last="Spector">Logan G. Spector</name>
<name sortKey="Zhang, Luoping" sort="Zhang, Luoping" uniqKey="Zhang L" first="Luoping" last="Zhang">Luoping Zhang</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name>
</noRegion>
<name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name>
</noRegion>
<name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name>
</country>
<country name="Grèce"><region name="Attique (région)"><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name>
</region>
<name sortKey="Baka, Margarita" sort="Baka, Margarita" uniqKey="Baka M" first="Margarita" last="Baka">Margarita Baka</name>
<name sortKey="Moschovi, Maria" sort="Moschovi, Maria" uniqKey="Moschovi M" first="Maria" last="Moschovi">Maria Moschovi</name>
</country>
<country name="Australie"><noRegion><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name>
</noRegion>
<name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name>
<name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K" last="Armstrong">Bruce K. Armstrong</name>
<name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D" last="Dockerty">John D. Dockerty</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D00 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D00 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4572913
   |texte=   Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26061779" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium

Home pesticide exposures and risk of childhood leukemia: Findings from the Childhood Leukemia International Consortium

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.